What does the word C3a mean?
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Smaller fragment formed when C3 convertase splits C3 into C3a and C3b. C3a is a 77- amino acid peptide that includes a carboxy- terminal arginine which is crucial for its biological activities. C3a causes symptoms of immediate hypersensitivity ( anaphylaxis) including smooth muscle contraction, mast cell histamine release, and local inflammation. It is considered an anaphylatoxin along with C4a, C5a, and C5a des- arginine.
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