What does the word GABA B Receptor mean?
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Cell surface proteins which bind GAMMA- AMINOBUTYRIC ACID and influence cells via interactions with G- proteins. GABA- B receptors are pharmacologically characterized by their insensitivity to the blocker bicuculline and sensitivity to the agonist L- baclofen. They are found both presynaptically and postsynaptically, and act variously by inhibition of adenylate cyclase, activation of phospholipase A2, activation of potassium channels, and inactivation of voltage- activated calcium channels.
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