What does the word GABA Modulators mean?

  • Substances that do not act as agonists or antagonists but do affect the GAMMA- AMINOBUTYRIC ACID receptor- ionophore complex. GABA- A receptors ( RECEPTORS, GABA- A) appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of GAMMA- AMINOBUTYRIC ACID- activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. General anesthetics probably act at least partly by potentiating GABAergic responses, but they are not included here.

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